D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis
发表时间：2014-12-17 14:14
Abstract
No early serum marker of disease severitycontributesto the treatment decision-making process of acute superior mesenteric venous thrombosis (ASMVT). This study aims to assess the value of serum D- dimer level in the first 3 days after admission as a severity marker of ASMVT patients. From May 2010 to June 2014, 50 consecutive patients of ASMVT were enrolled in this observational study. The serum D-dimer level was measured on a daily basis during the first 3 days after admission as well as other laboratory-testing parameters, clinical score, and outcome variables recorded during the same period. The maximum and mean D-dimer values were analyzed and compared with other potential markers for prediction of multiple-organ dysfunction syndrome (MODS) and short-bowel syndrome (SBS). The correlation of D-dimer levelwith other potential severitymarkersand inflammationparameters were also studied. Both maximum and mean D-dimer level during the first 3 days of admission were significantly higher in patients with several clinical variables such as death within 30 days, bowel resection, sepsis, abdomi- nal compartment syndrome, MODS, and SBS. In addition, serum D- dimer level showed precise prediction for MODS and SBS, greater than L -lactateandintestinal-typefattyacid-bindingprotein(I-FABP).TheD- dimerlevelwas correlated well with L -lactate,I-FABP, andAPACHEII score on the first 3 days of admission. Poor correlation of D-dimer level and inflammation parameters, white blood cell count, and C-reactive protein level, was detected. D-dimer level could be an effective, early, and specific serum marker indicating the clinical evolution and outcome of ASMVT.
第一署名医院：南京军区南京总医院
