研究论文
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发表时间:2017-07-23 13:51

背景与目的:静脉曲张出血是肝硬化门脉高压的严重并发症。30%患者在首次出血事件中死亡,而60%-70%的生存者有再次出血的危险。因此,所有发生出血后存活的患者都应当积极预防再出血。门静脉血栓在肝硬化患者中患病率为10-25%,而门静脉血栓的形成可显著增加肝硬化患者的静脉曲张急性出血控制失败率,再出血率及六周死亡率,使得静脉曲张出血的治疗和预防更加复杂和困难。对于没...

发表时间:2015-12-17 13:20

The Leucine zipper tumor suppressor gene 1 (LZTS1/FEZ1) gene was originally identified as a potential tumor suppressor. However, the expression pattern and the role of LZTS1 in the progression of colorectal cancer (CRC) have not been well characterized. Herein, we reported that LZTS1 was markedly...

发表时间:2015-12-17 13:15

Ileal Crohn’s disease (CD) arising from the alteration of intestinal homeostasis is characterized by two features, namely a decrease in Paneth cell-produced antimicrobial peptides that play a key role in maintaining this balance and an increase in NOD2, an intracellular sensor. Although mutations in NOD2...

发表时间:2015-12-16 15:58

Cancer initiating cells (CICs) are responsible for the unrestrained cell growth and chemoresistance of malignant tumors. Histone demethylation has been shown to be crucial for self-renewal/differentiation of stem cells, but it remains elusive whether lysine- specific demethylase 1 (LSD1) regulates the stemness properties of CICs....

发表时间:2015-12-11 16:32

Intestinal fungi are increasingly believed to greatly influence gut health. However, the effects of fungi on intestinal inflammation and on gut bacterial constitution are not clear. Here, based on pyrosequencing method, we reveal that fungal compositions vary in different intestinal segments (ileum, cecum, and colon),...