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发表时间:2019-07-23 13:51

背景与目的:慢性萎缩性胃炎患者的胃肠化生(IM)常见于胃上皮。IM中CDX2的激活是由胆汁酸回流和慢性炎症引起的。但是,胆汁酸如何激活胃上皮细胞中CDx2的机制还没有得到充分的探讨。 方法:用微阵列技术对胆汁酸处理的细胞进行小RNA和mRNA分析。利用Go分析和生物信息学对小RNA/mRNA谱进行数据整合,以检测潜在的小RNA mRNA调节电路。...

发表时间:2018-09-23 13:30

背景与目的:研究显示对肝功能Child-Pugh C级或Child-Pugh B级伴有内镜下活动性出血的患者,早期(出血后72h内)行覆膜支架TIPS,与药物联合内镜治疗相比提高患者的生存率。但是,早期 TIPS的最佳适应人群仍然存在争议。首先,在随后的三项根据early-TIPS标准纳入“高危”患者的观察性研究中,早期TIPS与标准治疗相比并没有明显延长生存。其次,一些研究发现对于Child-Pugh B级伴有活动性出血的患者并不属于真正的高危患者,因此不需要进行早期TIPS治疗。一些学者提出了其他定义急性静脉曲张出血“高危”患者的标准,如终末期肝病...

发表时间:2017-07-23 13:51

背景与目的:静脉曲张出血是肝硬化门脉高压的严重并发症。30%患者在首次出血事件中死亡,而60%-70%的生存者有再次出血的危险。因此,所有发生出血后存活的患者都应当积极预防再出血。门静脉血栓在肝硬化患者中患病率为10-25%,而门静脉血栓的形成可显著增加肝硬化患者的静脉曲张急性出血控制失败率,再出血率及六周死亡率,使得静脉曲张出血的治疗和预防更加复杂和困难。对于没...

发表时间:2015-12-17 13:20

The Leucine zipper tumor suppressor gene 1 (LZTS1/FEZ1) gene was originally identified as a potential tumor suppressor. However, the expression pattern and the role of LZTS1 in the progression of colorectal cancer (CRC) have not been well characterized. Herein, we reported that LZTS1 was markedly...

发表时间:2015-12-17 13:15

Ileal Crohn’s disease (CD) arising from the alteration of intestinal homeostasis is characterized by two features, namely a decrease in Paneth cell-produced antimicrobial peptides that play a key role in maintaining this balance and an increase in NOD2, an intracellular sensor. Although mutations in NOD2...

发表时间:2015-12-16 15:58

Cancer initiating cells (CICs) are responsible for the unrestrained cell growth and chemoresistance of malignant tumors. Histone demethylation has been shown to be crucial for self-renewal/differentiation of stem cells, but it remains elusive whether lysine- specific demethylase 1 (LSD1) regulates the stemness properties of CICs....

发表时间:2015-12-11 16:32

Intestinal fungi are increasingly believed to greatly influence gut health. However, the effects of fungi on intestinal inflammation and on gut bacterial constitution are not clear. Here, based on pyrosequencing method, we reveal that fungal compositions vary in different intestinal segments (ileum, cecum, and colon),...